• Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function 

      Hande, Liv Nesse; Thunhaug, Hilde; Enebakk, Terje; Ludviksen, Judith K; Pettersen, Kristin; Hovland, Anders; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)
      <i>Background</i> - Prestatin trials reported positive effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in cardiovascular disease, whereas recent studies and meta-analyses have not reproduced these results. The effect of n-3 PUFA in patients with familial hypercholesterolemia (FH), a group with particularly high risk of cardiovascular disease, is not well established.<p><p> <i>Objective</i> ...
    • Health-related quality of life on tele-monitoring for users with pacemakers 6 months after implant: the NORDLAND study, a randomized trial 

      Lopez-Villegas, Antonio; Catalán-Matamoros, Daniel; Lopez-Liria, Remedios; Enebakk, Terje; Thunhaug, Hilde; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <i>Background</i>: With an ageing population and widening indications for pacemakers implantation, the number of persons carrying an implant is steadily increasing. The routine follow-up is thus a heavy burden for the respective NHS as well as for the patients and their relatives. Most of them of the studies have been performed in densely populated areas and nearby to the hospital. It is thus ...
    • No effect of omega-3 polyunsaturated fatty acid supplementation on inflammatory markers in familial hypercholesterolemia: a randomized crossover trial 

      Hande, Liv Nesse; Thunhaug, Hilde; Ludviksen, Judith K; Hovland, Anders Wilhelm; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)
      Individuals with familial hypercholesterolemia (FH) have increased cardiovascular risk despite lipid-lowering therapy, and additional therapy is warranted. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplements have demonstrated an effect on cardiovascular endpoints in some clinical trials. Platelet-modifying and anti-inflammatory properties are among the proposed beneficial effects of n-3 PUFA. ...
    • Reduced gut microbial diversity in familial hypercholesterolemia with no effect of omega-3 polyunsaturated fatty acids intervention–a pilot trial 

      Larsen, Christopher Storm; Hande, Liv Nesse; Kummen, Martin; Thunhaug, Hilde; Vestad, Beate; Hansen, Simen Hyll; Hovland, Anders Wilhelm; Trøseid, Marius; Lappegård, Knut Tore; Hov, Johannes Espolin Roksund (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-01)
      Individuals with familial hypercholesterolemia (FH) undergo an aggressive treatment with cholesterollowering drugs to prevent coronary heart disease. Recent evidence suggests an interplay between the gut microbiota, blood lipid levels and lipid-lowering drugs, but this has yet to be studied in individuals with FH. The objective of the study was to characterize the gut microbiota of individuals ...
    • Telemonitoring and quality of life in patients after 12 months following a pacemaker implant: The Nordland study, a randomised trial 

      Lopez-Liria, Remedios; Lopez-Villegas, Antonio; Enebakk, Terje; Thunhaug, Hilde; Lappegård, Knut Tore; Catalán-Matamoros, Daniel (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-05)
      The purpose of this study was to analyse the health-related quality of life (HRQoL) of patients followed up using a remote device-monitoring system (TM) compared to patients followed up through standard outpatient visits (HM), 12 months after the implantation of a pacemaker. This was a trial design that used the EuroQol-5D Questionnaire and the Minnesota Living with Heart Failure Questionnaire (MLHF). ...